The movie is based on the Tony Award-winning, semi-autobiographical play by Larry Kramer, which chronicles the life of gay and HIV activists in New York City from 1981 to 1984.
Ruffalo will play the main character, gay activists Ned Weeks; Baldwin will play Weeks' homophobic brother; and Roberts will play Dr. Emma Brookner, one of the few health officials in New York to be taking the disease seriously.
Jim Parsons, one of the stars of "Big Bang Theory," has appeared in Broadway version of "The Normal Heart" and will reprise his role as a Southern gay activist.
Ruffalo, who is straight, has been active in helping the gay community, and headlined a fundraiser for a small gay club in his hometown of Kenosha, Wisc., last year.
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